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KMID : 0388120090180030094
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Journal of Korean Society for the Study of Obesity
2009 Volume.18 No. 3 p.94 ~ p.101
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Changes of inflammatory markers as the changes of obesity prevalence in middle-aged Korean men
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Kim Kwang-Min
Kim Bom-Taeck
Park Sat-Byul
Joo Nam-Seok
Choi Seung-Hwa
Lee Duck-Joo
Kim Sang-Man
Kim Bo-Young
Kim Kyu-Nam
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Abstract
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Background: The prevalence of obesity has been increasing recently and obesity is thought to play a key role in atherosclerosis through low-grade chronic inflammation. In this study, we evaluated the relation of changes in inflammatory markers under the prevalence of obesity.
Methods: We evaluated the data of 6,095 middle-aged men, who visited the health promotion center of a hospital in 2004 and 2006. WBC count, uric acid, hsCRP, fibrinogen and homocysteine were used as markers of inflammation. We compared anthropometry, parameters of metabolic syndrome, prevalence of obesity and changes in inflammatory markers.
Results: In comparison with the prevalence of obesity, central obesity and metabolic syndrome in 2004 (39.0%, 24.3%, and 25.3%, respectively), the prevalence increased to 41.9%, 30.2%, 27.5% in 2006, respectively. (p<0.05) There was no significant difference in parameters of metabolic syndrome between 2 years. Among inflammatory markers, WBC count increased from 6.256±1.325 x 10³/uL in 2004 to 6.387±1.344 x 10³/uL in 2006, (p<0.001) and hsCRP increased from 0.111±0.108mg/dl in 2004 to 0.122±0.129mg/dl in 2006. (p=0.005) Fibrinogen increased from 314.909±60.497mg/dl in 2004 to 343.685±62.186mg/dl in 2006(p<0.001). When we compared inflammatory markers under the presence of obesity, WBC count, uric acid and hsCRP increased in the obese, centrally obese and metabolic syndrome group. Comparing 2004 and 2006 data for changes in inflammatory markers between the obese group and centrally obese group, WBC and hsCRP showed a significant difference in respect to presence or absence of obesity and central obesity before and after adjustment for age, smoking, alcohol intake, fasting glucose, and blood pressure.
Conclusion: Increase in prevalence of obesity may be associated with an increase in WBC count and hsCRP level before change in metabolic risk factors in middle aged men.
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KEYWORD
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obesity prevalence, inflammation, WBC count, hsCRP
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